Model Analysis of Helper T Cell Differentiation
نویسندگان
چکیده
Helper T (Th) cells regulate immune responses by producing various cytokines upon antigen stimulation. Helper T cells can be divided into two subsets, Th1 and Th2 [2]. The Th1 cells are responsible for defense against infectious intracellular microorganisms. The Th2 cells are responsible for defense against extracellular pathogens and the development of allergic immune reactions. The SOCS family was reported to regulate Th differentiation [3, 4]. In order to analyze the balance of Th1/Th2 differentiation and the role of SOCS family, we developed the model of Th0 cells containing IL-4, IL-12 and IFN-γ JAK/STAT signal transduction pathway, which simulates the first stage of Th1/Th2 differentiation.
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